Loss of ephrin-A5 leads to clinical signs of Peters Anomaly in a mouse model.

Catherine Cheng, Isaiah J Innis, Michael P Vu, Yuka Okada

Abstract read

In one paragraph

Article in Experimental eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catherine ChengSchool of Optometry and Vision Science Program, Indiana University, Bloomington, IN, United States. Electronic address: ckcheng@iu.edu.

Isaiah J InnisSchool of Optometry and Vision Science Program, Indiana University, Bloomington, IN, United States.

Michael P VuSchool of Optometry and Vision Science Program, Indiana University, Bloomington, IN, United States.

Yuka OkadaDepartment of Ophthalmology, Wakayama Medical University, School of Medicine, Wakayama, Japan.

Funding

Eph-ephrin signaling in the lensR01EY032056 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI CHENG, CATHERINE KEHSIN · 2021 to 2025

$2.3M

NEI NIH HHS R01 EY032056

6 · The paper itself

Abstract

Peters Anomaly (PA) is the leading cause for corneal transplants in pediatric patients. We investigated whether disruption of Eph-ephrin signaling leads to phenotypes associated with PA, including microphthalmia, cloudy cornea, coloboma, cataract, corneo-lenticular touch (CLT), irido-corneal adhesion (ICA), and persistent fetal vasculature (PFV). Freshly enucleated mouse eyes were imaged under a dissection microscope, and high-resolution confocal images were collected to compare mouse eyes with genetic disruption of EphA2 or ephrin-A5. In ephrin-A5 knockout (KO or

Identifiers

PMID42665223

DOI10.1016/j.exer.2026.111226

PMCPMC13563214

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.