ArticleJHEP reports : innovation in hepatology2026
Atezolizumab-bevacizumab with or without cisplatin-based HAIC for unresectable HCC: A randomized phase II trial.
Article in JHEP reports : innovation in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsAtezolizumab plus bevacizumab (ATZ/BEV) is the global standard first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the objective response rate (ORR) is approximately 30%. Hepatic arterial infusion chemotherapy (HAIC) with cisplatin may enhance its efficacy through locoregional cytoreduction and immunological modulation. We conducted a randomized phase II trial to evaluate whether sequential cisplatin HAIC plus ATZ/BEV (CDDP+ATZ/BEV) improves clinical outcomes compared to ATZ/BEV alone.
methodsIn this multicenter, open-label trial, patients with unresectable HCC were randomized 1:1 to receive cisplatin HAIC within 8 weeks before initiation of ATZ/BEV or ATZ/BEV alone. The primary endpoint was ORR.
resultsBetween December 2021 and December 2024, 70 patients were enrolled in this study (CDDP+ATZ/BEV, n = 35; ATZ/BEV, n = 35). The primary endpoint, ORR, was numerically higher in the CDDP+ATZ/BEV group than in the ATZ/BEV group but did not reach statistical significance (45.7% vs. 28.6%; p = 0.095). Median progression-free survival (PFS) was longer in the CDDP+ATZ/BEV group (8.3 vs. 6.6 months; HR 0.53; p = 0.036), and median duration of response was not reached vs. 4.6 months (HR 0.4; p = 0.11). The median overall survival (OS) was 28.1 vs. 31.0 months (HR 0.95; p = 0.88). Grade 3-4 treatment-related adverse events occurred in 20.0% and 22.9% of patients, respectively.
conclusionsThe primary endpoint of ORR was not met. However, exploratory analyses demonstrated longer PFS without additional safety concerns. Further evaluation in phase III trials is warranted. IMPACT AND IMPLICATIONS: This multicenter randomized phase II trial provides evidence that sequential cisplatin hepatic arterial infusion chemotherapy followed by atezolizumab-bevacizumab may prolong disease control without increasing toxicity in patients with unresectable hepatocellular carcinoma. Although the primary endpoint was not met and the progression-free survival benefit was observed in exploratory analyses, these findings support further investigation of this strategy in phase III trials and provide a rationale for evaluating liver-directed combination approaches to optimize first-line immunotherapy. CLINICAL TRIAL NUMBER: Japan Registry of Clinical Trials (jRCTs061210065).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.