Evidence map›Paper›PMID 42664974›Full record

ArticleCell metabolism2026

Host metadherin coordinates hepatic lipid metabolism and CD8

Yong Tang, Ziqing Chen, Hirak Sarkar, Yong Wei, Sereno L Lopez-Darwin, Asael Roichman, Ji Woo Park, Qinglan Li, Cao Fang, Zihong Chen and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yong TangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Ziqing ChenDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Hirak SarkarDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Yong WeiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Sereno L Lopez-DarwinLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Asael RoichmanLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Ji Woo ParkDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Qinglan LiDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cao FangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Zihong ChenLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
James GowDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Minhong ShenDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Jennifer ShiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Lifei JiangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Richard KlarSecarna Pharmaceuticals GmbH & Co. KG, Am Klopferspitz 19, Planegg/Martinsried 82152, Germany.
Xiang HangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Janette R LugoDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Christina J DeCosteDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Jennifer M MillerLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Wei WangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Peter RomanienkoGenome Editing Shared Resource, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Alana L WelmDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Ileana M CristeaDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Liling WanDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joshua D RabinowitzLudwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Yibin KangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA; Cancer Metabolism and Growth Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA. Electronic address: ykang@princeton.edu.

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Methods and Logic in Molecular Biology Training ProgramT32GM148739 · NIGMS · PRINCETON UNIVERSITY · PI Ileana M. Cristea · 2023 to 2026
$3.6M
Dynamic virus-driven remodeling of ER-mitochondria contactsR01AI174515 · NIAID · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 2022 to 2025
$2.2M
NCI NIH HHS P30 CA072720NIAID NIH HHS R01 AI174515NIGMS NIH HHS T32 GM148739
6 · The paper itself

Abstract

Cancer progression is systemically influenced by distant organ dysfunction induced by primary tumors, yet how long-distance tumor-organ crosstalk regulates antitumor immunity remains unclear. Here, we identify host metadherin (MTDH) as a critical regulator of tumor-induced immunosuppression and metabolic reprogramming via tumor-liver interactions. Using Mtdh knockout mouse models, we show that concurrent MTDH loss in hepatocytes and CD8

Indexed as

CD8-Positive T-LymphocytesCell Adhesion MoleculesLipid MetabolismLiverMembrane ProteinsRNA-Binding ProteinsAnimalsDisease ProgressionHepatocytesHumansKupffer CellsMetabolic ReprogrammingMiceMice, Inbred C57BLMice, KnockoutCell Adhesion MoleculesMembrane ProteinsMtdh protein, mouseRNA-Binding ProteinsCD8(+) T cellsEVPextracellular vesicles and particlesimmunotherapylipid metabolismMTDHPPARαtumor-liver interaction

Identifiers

PMID42664974
PMCPMC13623212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.