Evidence map›Paper›PMID 42664960›Full record

ArticleImmunity2026

A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.

Dan Yuan, Sarah Li, Rongyu Zhang, Rachel H Ng, Yapeng Su, Linda Lan, Mahasish Shome, Brett Smith, Pamela Troisch, Jingyi Xie and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Dan YuanInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Sarah LiInstitute for Systems Biology, Seattle, WA 98109, USA.
Rongyu ZhangInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Rachel H NgInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Yapeng SuVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Linda LanDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Mahasish ShomeDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Brett SmithInstitute for Systems Biology, Seattle, WA 98109, USA.
Pamela TroischInstitute for Systems Biology, Seattle, WA 98109, USA.
Jingyi XieInstitute for Systems Biology, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA.
Jongchan ChoiInstitute for Systems Biology, Seattle, WA 98109, USA.
Rick EdmarkInstitute for Systems Biology, Seattle, WA 98109, USA.
Daniel ChenInstitute for Systems Biology, Seattle, WA 98109, USA.
Lee RowenInstitute for Systems Biology, Seattle, WA 98109, USA.
Amy NguyenInstitute for Systems Biology, Seattle, WA 98109, USA.
Rachel LiuInstitute for Systems Biology, Seattle, WA 98109, USA.
Vanessa GutierrezInstitute for Systems Biology, Seattle, WA 98109, USA.
Conor BrennanInstitute for Systems Biology, Seattle, WA 98109, USA.
Michaela McKassonInstitute for Systems Biology, Seattle, WA 98109, USA.
Kim MurrayInstitute for Systems Biology, Seattle, WA 98109, USA.
Julie A WallickSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Heather A AlgrenSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA.
Alexandria DuvenSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA.
Brian PieningProvidence St. Joseph Health, Renton, WA 98057, USA.
Wendy ThomasDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Hao Y KuehDepartment of Bioengineering, University of Washington, Seattle, WA 98105, USA.
Andrew T MagisInstitute for Systems Biology, Seattle, WA 98109, USA.
Jennifer HadlockInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195, USA.
Michael SnyderDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Jason D GoldmanSwedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
James R HeathInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. Electronic address: jim.heath@isbscience.org.

Funding

OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Center for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8M
Nano and biomolecular engineered technologies for neoantigen-specific T cell capture and characterizationR01CA264090 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI HEATH, JAMES R. · 2021 to 2025
$2.7M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA264090NHGRI NIH HHS RM1 HG007735NHLBI NIH HHS OT2 HL161847
6 · The paper itself

Abstract

Autoantibodies (autoAbs) are linked to mortality and Long COVID, yet their cellular origins remain unclear. We analyzed the INCOV cohort and identified 12 age- and sex-matched participants with varying autoAb abundance and integrated single-cell RNA-seq and ATAC-seq data from B cells, plasma proteomics, proteome-wide autoAb profiling, clinical data, and in vitro assays. AutoAb abundance inversely correlated with neutralizing IgG and declined as infection resolved, paralleling the contraction of atypical memory B cells (AtMs). In vitro, AtMs preferentially differentiated into autoAb-producing antibody-secreting cells upon TLR7/8 stimulation. CD11c

Indexed as

autoantibodiesB cellLong COVIDmulti-omics

Identifiers

PMID42664960
PMCPMC13577201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.