Evidence map›Paper›PMID 42664385›Full record

ArticleThe Journal of physiology2026

Adipose FGF21 signalling mediates the anti-senescence effects of protein restriction.

Xiaohan Yang, Yanni Wu, Yi Yang, Long Huang, Xianyang Jin, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaohan Yang *Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0009-0008-6651-6022
Yanni Wu *Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Yi YangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Long HuangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Xianyang JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Xuemei JiangAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Chao JinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Bin FengAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0001-6258-2729
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Yan LinAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
De WuAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Lun HuaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0009-0000-6816-5192

Funding

National Key R&D Program of China 2023YFD1300804/5National Natural Science Foundation of China 32230102National Natural Science Foundation of China 32472948
6 · The paper itself

Abstract

Dietary protein restriction (PR) is a well-recognized nutritional intervention that enhances metabolic health and extends lifespan. However, the mechanisms behind this phenomenon are not well understood. Here, using genetic loss-of-function models for fibroblast growth factor 21 (Fgf21) and its obligate co-receptor β-Klotho (Klb), we demonstrate that FGF21-KLB signalling in adipocytes is indispensable for the anti-senescence effects of PR. Specifically, adipocyte FGF21 signalling preserves mitochondrial integrity, maintains an anti-inflammatory milieu and sustains nicotinamide adenine dinucleotide (NAD

Indexed as

AdipocytesAdipose TissueCellular SenescenceDiet, Protein-RestrictedFibroblast Growth Factors3T3-L1 CellsAMP-Activated Protein KinasesAnimalsKlotho ProteinsMembrane ProteinsMiceMice, Inbred C57BLMitochondriaNADSignal TransductionAMP-Activated Protein Kinasesfibroblast growth factor 21Fibroblast Growth FactorsKlb protein, mouseKlotho ProteinsMembrane ProteinsNADfibroblast growth factor 21 (FGF21)mitochondrial integrityNAD+ homeostasisprotein restrictionwhite adipose tissue (WAT)

Identifiers

PMID42664385
PMCPMC13577684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.