Evidence map›Paper›PMID 42664351›Full record

ArticleScience advances2026

The structure of the dopamine D

Eliane Hadas Yardeni, Dóra Judit Kiss, Julie Sanchez, Keshet Shavit, Dénes Szepesi Kovács, Attila Egyed, Caleb D Vogt, Supriya A Gaitonde, Jacqueline Glenn, Meritxell Canals and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eliane Hadas YardeniDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID 0009-0007-3898-5035
Dóra Judit KissMedicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.ORCID 0000-0002-6664-3872
Julie SanchezDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-5765-4342
Keshet ShavitDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-1343-2481
Dénes Szepesi KovácsMedicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
Attila EgyedMedicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.ORCID 0000-0001-8463-4219
Caleb D VogtMolecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Supriya A GaitondeInstitute for Research in Immunology and Cancer, Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.
Jacqueline GlennDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID 0009-0008-0608-2744
Meritxell CanalsDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-7942-5006
Michel BouvierInstitute for Research in Immunology and Cancer, Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.ORCID 0000-0003-1128-0100
Amy Hauck NewmanMolecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.ORCID 0000-0001-9065-4072
J Robert LaneDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-7361-7875
György M KeserűMedicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.ORCID 0000-0003-1039-7809
Moran Shalev-BenamiDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-6902-1924

Funding

NOVEL DOPAMINE D3 RECEPTOR LIGANDSZ01DA000424 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI NEWMAN, AMY HAUCK · 1999 to 2008
$1.8M
Intramural NIH HHS Z01 DA000424
6 · The paper itself

Abstract

The third-generation antipsychotic cariprazine is a low-efficacy partial agonist of the dopamine D

Indexed as

Dopamine AgonistsPiperazinesReceptors, Dopamine D3Antipsychotic AgentsBinding SitesCryoelectron MicroscopyDrug Partial AgonismHumansLigandsMolecular Dynamics SimulationProtein BindingAntipsychotic AgentscariprazineDopamine AgonistsLigandsPiperazinesReceptors, Dopamine D3

Identifiers

PMID42664351
PMCPMC13524052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.