Evidence map›Paper›PMID 42664326›Full record

ArticleScience advances2026

Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling.

Miranda L Lopez, Taekyung Kang, Ana M Espeleta, Varvara I Rubtsova, Jongwon Baek, Jakob Songcuan, Elena M Moyer, Joohwan Kim, Won-Suk Song, Sunhee Jung and 24 more

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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Miranda L LopezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0000-0850-5693
Taekyung KangDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0005-3407-6710
Ana M EspeletaCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA.
Varvara I RubtsovaDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Jongwon BaekDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Jakob SongcuanDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Elena M MoyerDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0006-2137-4687
Joohwan KimDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA, USA.ORCID 0000-0002-2999-4411
Won-Suk SongDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Sunhee JungDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0001-5396-4813
Rochelle W LaiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0000-0003-1423-197X
Aiyana BinuyaDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Christopher H LeeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0008-9805-3835
Amy R LantzDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Nicholas D'SaDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Alexis AnicaDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA, USA.
Elise TranDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0003-3798-9852
Yujin ChunDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA, USA.ORCID 0000-0003-0308-3203
Wonsuk ChoiDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-0523-0839
Ki-Hong JangDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA, USA.ORCID 0000-0002-9914-8480
Sungji ChoDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-1311-0191
Miranda E KellyDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0003-2451-7207
Ian J TamburiniDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Yasmine H AlamDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Johnny LeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-0245-5848
Cuauhtemoc B RamirezDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0001-7182-1859
Raghu P KataruDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1315-7982
Seon Pyo HongCenter for Vascular Research, Institute for Basic Science, Daejeon, Korea.ORCID 0000-0002-9923-8099
Thomas Q de Aguiar VallimDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0000-0001-7642-5046
Dequina A NicholasDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-4996-2190
Katherine S XueDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-4094-3615
Gina LeeDepartment of Microbiology and Molecular Genetics, University of California Irvine School of Medicine, Irvine, CA, USA.ORCID 0000-0002-8120-9169
Hosung BaeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0001-5848-7972
Cholsoon JangDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0001-6651-4213

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
Elucidating alcohol-induced metabolic remodeling of critical organsR21AA030358 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON, SELDIN, MARCUS MICHAEL · 2023 to 2023
$412k
NIAAA NIH HHS R01 AA029124NIAAA NIH HHS R21 AA030358NIDDK NIH HHS P30 DK063491NIGMS NIH HHS T32 GM136624
6 · The paper itself

Abstract

High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and diabetes, yet the underlying mechanisms, especially at the specific organ level, are incompletely understood. Catabolism of dietary fructose primarily occurs in the small intestine and liver, with fructose breakdown in the liver being pathological, while small intestinal fructose clearance protects the liver. Here, we report that inhibition of fructose catabolism specifically in the murine small intestine unexpectedly mitigates fructose-induced obesity and insulin resistance. Such phenotypes are attributed to decreased dietary fat absorption by the shortening of ileal lacteals. Fecal transplantation experiments revealed that the microbiome altered by blunted host intestinal fructose catabolism decreases ileal macrophages essential for lacteal growth. Thus, altered intestinal lacteal architecture likely contributes to the synergistic effects of high fat and sugar on metabolic disorders. It may also be relevant to the clinical evidence that pharmacologic suppression of fructose catabolism mitigates diet-induced obesity.

Indexed as

FructoseIleumInsulin ResistanceObesityAnimalsMacrophagesMiceFructose

Identifiers

PMID42664326
PMCPMC13524015

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.