ArticlePloS one2026
Effect of longevity genotype on acute phase response to a lipopolysaccharide challenge in dairy goats.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
The present study aims to explore the phenotypic variability of the inflammatory response to a lipopolysaccharide (LPS) challenge in goats and compare the reaction between two lines divergently selected for functional longevity. Hyper-selection based on functional longevity successfully created two groups of goats with different lifespans (High_LGV and Low_LGV). Primiparous goats were injected intravenously with LPS to trigger an inflammatory response, with a total of 83 goats, including 42 High_LGV and 41 Low_LGV goats. Blood was sampled 12 times at -72, 0 (injection), 2, 4, 6, 8, 10, 12, 24, 48, 72, and 144 hours. Baseline cytokine concentrations (average of hours -72 and 0) showed no significant differences between longevity lines for any of the 14 measured cytokines. Among the six cytokines that responded to the LPS challenge (IFN-γ, IL4, IL-6, IL-10, MIP1α, and TNFα), three showed significant differences between longevity lines in their temporal response profiles. Low_LGV goats exhibited stronger acute inflammatory responses with greater IL-6 and IFN-γ concentrations during the early hours post-challenge, while High_LGV goats showed elevated MIP1α concentrations during the resolution phase. In parallel, whole blood was stimulated for 24 hours with LPS on a total of 157 goats for ex vivo assessment of the blood response. The IL-6 concentration measured in the whole blood assay showed a moderate correlation with the in vivo response and revealed no difference between the longevity lines. These results suggest that a stronger acute inflammatory response, characterised by elevated pro-inflammatory cytokine production, may be detrimental to functional longevity in dairy goats, possibly through increased tissue damage and impaired recovery following inflammatory challenges.
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