Evidence map›Paper›PMID 42664236›Full record

ArticlePloS one2026

Long-term effects of cognitive behavioural therapy on the quality of life in adult ADHD.

Ravian Wettstein, Valentina Navarro-Ovando, Viktoria Janke, Ron Mathôt, Glenn Dumont

Abstract read
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ravian WettsteinDedimo, Research and Development, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-6929-4770
Valentina Navarro-OvandoDepartment of Hospital Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Viktoria JankeDepartment of Hospital Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Ron MathôtDepartment of Hospital Pharmacy and Clinical Pharmacology, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Glenn DumontDedimo, Research and Development, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the long-term effects (4-8 years) of Cognitive Behavioural Therapy (CBT), added to pharmacotherapy and psychoeducation (PE), on quality of life (QoL) in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Although previous findings showed no added QoL benefit of CBT immediately post-treatment, CBT provides skill-building and coping strategies that may yield delayed benefits in terms of ADHD-related functional impairments. We hypothesize that CBT will provide delayed treatment gains and thus results in higher QoL at follow-up or a slower decline in QoL over time. A follow-up study was conducted with 627 adults from a prior cohort that evaluated short-term CBT outcomes. Of these, 159 participants completed a long-term follow-up survey assessing QoL using the Adult ADHD Quality of Life scale (AAQoL). A linear mixed model revealed no significant treatment or treatment-by-time effects for the total AAQoL or its subdomains. However, a significant effect of time was observed across all measures. Post hoc comparisons indicated an increase in QoL from baseline (pooled mean = 44.4; PsyEd: 46.4, PsyEd + CBT: 42.4) to post-treatment (69.3), followed by a decline at follow-up (52.1), which remained above baseline levels. No significant between-group differences were found in the proportion of participants achieving clinically meaningful QoL improvements over time. These findings suggest that this study does not provide evidence for an added long-term QoL benefit of CBT beyond PE and pharmacotherapy, whereas initial treatment was associated with sustained improvement. Continued care beyond initial treatment may help maintain gains in adults with ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityCognitive Behavioral TherapyQuality of LifeAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedTreatment Outcome

Identifiers

PMID42664236
PMCPMC13524267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.