ArticlePloS one2026
Colorectal Centre of Excellence (COCOE) Registry: A protocol for a prospective longitudinal cohort of children with Hirschsprung's disease and anorectal malformations in Canada.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07603232 (COCOE Registry), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
COCOE Registry: A Prospective Study of Children With Colorectal Conditions at a Canadian Children's Hospital
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0 citing papers in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hirschsprung's disease (HD) and anorectal malformations (ARM) are congenital colorectal conditions requiring lifelong multidisciplinary care, yet no prospective, longitudinal registry exists for affected children in Canada. We describe the protocol for the COCOE Registry, the first prospective cohort of paediatric patients with HD and ARM at the Colorectal Centre of Excellence (COCOE), Montreal Children's Hospital, McGill University Health Centre, Montréal, Québec, Canada. The registry enrolls children aged 0-17 years with a documented diagnosis of HD or ARM on a continuous basis, with follow-up until age 18. Clinical data are abstracted from a standardised multidisciplinary assessment form and entered into REDCap. Patient-reported outcomes are collected using six validated instruments spanning disease-specific quality of life, continence, general well-being, family functioning, parental adjustment, and bowel management experience. Statistical analyses will include descriptive summaries, group comparisons, survival analyses, and multivariable logistic regression to identify factors associated with key outcomes, reported in accordance with STROBE guidelines. Research ethics approval has been granted by the McGill University Health Centre Research Ethics Board (MUHC REB No. 2026-10997). This study is registered with ClinicalTrials.gov (NCT07603232). The COCOE Registry will generate longitudinal data to improve clinical follow-up, inform healthcare planning, support equitable transitions to adult care, and enable participation in international multicentre research.
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