Evidence map›Paper›PMID 42664052›Full record

ArticleCell reports2026

Core activation program and selective regional responsiveness of microglia during aging and parabiosis.

Huma Naz, Nannan Lu, Caroline C Escoubas, Leah Sager, Jinglin Xiong, Robert Pálovics, Shinnosuke Yamada, Anna V Molofsky, Tony Wyss-Coray, Qingyun Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Huma NazDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.
Caroline C EscoubasDepartment of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Leah SagerDepartment of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
Jinglin XiongDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.
Robert PálovicsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.
Shinnosuke YamadaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Anna V MolofskyDepartment of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, CA, USA.
Qingyun LiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA. Electronic address: qingyunli@wustl.edu.
Guoyan ZhaoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Funding

Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisR01NS123571 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2025
$3.6M
Dissecting the origin, regulation and function of microglial subsets in Alzheimer's diseaseR01AG078512 · NIA · WASHINGTON UNIVERSITY · PI Qingyun Li · 2023 to 2026
$2.2M
Physiologic roles of Type I interferon responsive microglia in brain developmentR01MH135137 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anna V Molofsky · 2024 to 2026
$2.0M
Optimization of imaging mass cytometry, a single-cell spatial proteomics technology, for the study of Alzheimer diseaseR21AG077643 · NIA · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2022 to 2022
$433k
Define molecular events driving selective neuronal death in multiple neurodegenerative diseases by snRNA-seqR03AG070474 · NIA · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2022
$315k
American Heart Association-American Stroke Association 23BHCICG1188316 - NANNAN LUNIA NIH HHS R01 AG078512NIA NIH HHS R03 AG070474NIA NIH HHS R21 AG077643NIMH NIH HHS R01 MH135137NINDS NIH HHS R01 NS123571
6 · The paper itself

Abstract

Aging is associated with immune dysregulation in the brain and is the greatest risk factor for many neurodegenerative diseases. Rejuvenation interventions can mediate beneficial effects. Microglia are major contributors to neurodegenerative disease progression; however, the molecular changes underlying brain aging and rejuvenation remain poorly understood at the single-cell level. We identified and benchmarked several reproducible microglial states and a core set of genes that drive microglial activation in the mouse brain. We investigated microglial heterogeneity and examined the impact of aging and parabiosis-mediated exposure to young and old blood on microglial subpopulations across four brain regions: the cerebellum, cortex, hippocampus, and striatum. We revealed region-specific differences in microglial composition and age-related changes. The cerebellum consistently emerged as the most responsive region, whereas the striatum showed minimal responsiveness to parabiosis interventions. These findings highlight regional vulnerability and inform microglia-targeted strategies to modulate brain aging.

Indexed as

AgingMicrogliaParabiosisAnimalsBrainMaleMiceMice, Inbred C57BLagingcore activation signaturesCP: neurosciencemicrogliaregional vulnerabilityrejuvenationsingle-cell transcriptomics

Identifiers

PMID42664052
PMCPMC13690084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.