Evidence map›Paper›PMID 42664046›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

IFITM3 Is Elevated in BAL and Plasma Following Infection in ICU Setting.

Srabani Das, Carleen R Spitzer, Paul Consiglio, Matthew C Exline, Anasuya Sarkar

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Srabani DasDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Carleen R SpitzerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Paul ConsiglioDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Matthew C ExlineDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Anasuya SarkarDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0001-8910-0857

Funding

GasderminD regulation of Acute Lung InjuryR01HL160947 · NHLBI · OHIO STATE UNIVERSITY · PI SARKAR, ANASUYA · 2022 to 2025
$2.3M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH/NHLBI HL160947NHLBI NIH HHS R01 HL160947
6 · The paper itself

Abstract

Interferon-induced transmembrane protein 3 (IFITM3) is an antiviral protein with emerging roles in regulating inflammatory pathways. Although much is known about the role of IFITM3 in mediating host antiviral defense, its contribution to systemic immune responses during critical infectious illnesses remains less understood. Here, we provide evidence that IFITM3 levels were significantly higher in cell free BAL fluid in septic patients with pulmonary infections and in circulating plasma extracellular vesicles (EVs) from critically ill septic patients compared to critically ill non-septic patients and healthy individuals. This study provides the first evidence of IFITM3's association with sepsis induced inflammatory responses and bacterial pulmonary infections, raising its potential as an agent of dysregulated immunity during systemic infection.

Indexed as

Bronchoalveolar Lavage FluidMembrane ProteinsRNA-Binding ProteinsSepsisCritical IllnessExtracellular VesiclesFemaleHumansIntensive Care UnitsMaleIFITM3 protein, humanMembrane ProteinsRNA-Binding Proteinsextracellular vesiclesIFITM3pulmonary infectionssepsis

Identifiers

PMID42664046
PMCPMC13524198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.