Evidence map›Paper›PMID 42664029›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

d-Sorbose Promotes Regulatory T-Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition.

Fumiaki Sato, Masato Hoshi, Hiroyuki Yokoi, Sayaka Yoshida, Ryosuke Takenaka, Nao Shimoga, Nanaka Morita, Chieko Tashita, Kyoka Yamazaki, Yuka Kishimoto and 3 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fumiaki SatoDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0009-0004-7636-4481
Masato HoshiDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0000-0001-6260-8300
Hiroyuki YokoiDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0009-0003-2126-817X
Sayaka YoshidaDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0009-0003-2554-1348
Ryosuke TakenakaDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0009-0000-4553-1217
Nao ShimogaDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0009-0005-5728-319X
Nanaka MoritaDepartment of Medical Science Technology, School of Health Science at Narita, International University of Health and Welfare, Narita, Chiba, Japan.ORCID https://orcid.org/0009-0007-4656-7124
Chieko TashitaDepartment of Medical Technology, Gifu University of Medical Science, Seki, Gifu, Japan.ORCID https://orcid.org/0000-0002-4124-3581
Kyoka YamazakiResearch and Development, Matsutani Chemical Industry Co. Ltd., Itami, Hyogo, Japan.ORCID https://orcid.org/0009-0005-6803-2011
Yuka KishimotoResearch and Development, Matsutani Chemical Industry Co. Ltd., Itami, Hyogo, Japan.ORCID https://orcid.org/0000-0002-4591-5111
Hiroyuki TezukaDepartment of Cellular Function Analysis, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi, Japan.ORCID https://orcid.org/0000-0003-4209-9486
Hiroyasu ItoDepartment of Disease Systems Analysis Medicine, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0000-0002-4836-4001
Kuniaki SaitoDepartment of Advanced Diagnostic System Development, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.ORCID https://orcid.org/0000-0001-5800-9305

Funding

Fujita Health UniversityMatsutani Chemical Industry Co., Ltd.MEXT | Japan Society for the Promotion of Science (JSPS) 25K14944
6 · The paper itself

Abstract

Monosaccharides are fundamental biomolecules involved in various biological processes. Rare sugars, naturally scarce monosaccharide derivatives, exhibit unique physiological effects independent of standard energy metabolism. Among them, d-sorbose, the C-3 epimer of d-fructose, has poorly understood biological functions. This study investigated the immunometabolic effects of d-sorbose, focusing on regulatory T-cell (Treg) differentiation and immune modulation. Ex vivo assays using splenic naïve CD4

Indexed as

Biosynthetic PathwaysCell DifferentiationDiabetes Mellitus, Type 1HexosaminesHypersensitivityT-Lymphocytes, RegulatoryAnimalsMiceMice, Inbred C57BLMice, Inbred NODHexosaminesd‐sorbosehexosamine biosynthetic pathwaynon‐obese diabetes (NOD) modelOVA‐induced asthma modelrare sugarregulatory T cell

Identifiers

PMID42664029
PMCPMC13524200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.