Evidence map›Paper›PMID 42663960›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Polymer Translocation Through a Nanopore.

Kuo Chen, Murugappan Muthukumar

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kuo ChenDepartment of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003, USA.ORCID http://orcid.org/0000-0002-0459-4139
Murugappan MuthukumarDepartment of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003, USA. muthu@umass.edu.ORCID http://orcid.org/0000-0001-7872-4883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymers with distinct topologies-such as linear, star-shaped, ring, and bottlebrush architectures-exhibit diverse translocation behaviors when driven through solid-state nanopores due to differences in flexibility, hydrodynamic size, and steric interactions. These properties enable topology-sensitive single-molecule analysis. In this protocol, we describe detailed procedures for the electrophoretic translocation of PEG-based linear and star polymers through individual nanopores. This method enables precise characterization of polymer conformation and transport kinetics, with differences in dwell time, capture rate, and current blockage amplitude reflecting molecular architecture. The approach offers a practical platform for investigating polymer dynamics under nanoconfinement and supports topology-based analysis and separation.

Indexed as

NanoporesPolymersElectrophoresisKineticsPolyethylene GlycolsSingle Molecule ImagingPolyethylene GlycolsPolymersElectrophoretic transportMolecular conformationNanopore translocationPEG-based polymerPolymer topologySingle-molecule analysisTopology-sensitive detection

Identifiers

PMID42663960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.