A Cyclodextrin-Mediated Host-Guest Interactions Within α-Hemolysin Nanopore Platform for PFAS Identification.

Jaeon Cho, Lijun Peng, Chang Liu

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Jaeon ChoDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, 01003, USA.

Lijun PengDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, 01003, USA.

Chang LiuDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA, 01003, USA. chang@umass.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a category of persistent and extensively spread environmental contaminants that have raised significant global concerns. Liquid chromatography-tandem mass spectrometry (LC-MS/MS), a conventional detection gold standard, can accurately identify them, but its drawbacks include high costs, complicated procedures, and limited portability. Therefore, we developed a nanopore-based single-molecule sensing platform that combines cyclodextrin (CD) host-guest interactions to achieve precise identification of PFAS. By employing an α-hemolysin (α-HL) biological nanopore, when each CD-PFAS complex interacts with the pore, it creates a unique ionic current blockade that discriminates homologous compounds for single-molecular sensing, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Molecular dynamics simulations combined with experimental data reveal the structural and energetic foundations of CD-PFAS interactions. This work demonstrates a sensitive and selective platform for PFAS monitoring, paving the way toward environmental protection.

Indexed as

Alkanesulfonic AcidsCaprylatesCyclodextrinsEnvironmental PollutantsFluorocarbonsHemolysin ProteinsNanoporesMolecular Dynamics SimulationTandem Mass SpectrometryAlkanesulfonic AcidsCaprylatesCyclodextrinsEnvironmental PollutantsFluorocarbonsHemolysin Proteinsperfluorooctane sulfonic acidperfluorooctanoic acidCyclodextrinEnvironmental monitoringHost–guest interactionNanopore sensingPFASSingle-molecule analysis

Identifiers

PMID42663954

DOI10.1021/acsami.1c14043

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.