Evidence map›Paper›PMID 42663898›Full record

ArticleJournal of patient-reported outcomes2026

Development of the Physical Distancing Scale for COVID-19 Avoidance (PDS-C19©) in immunocompromised and non-immunocompromised individuals and its validation in the EAGLE Study.

James C Marcus, Tiago Maia, Paul Williams, Renata T C Yokota, Sofie Arnetorp, Timothy A Herring, Sudhir Venkatesan, Philip A Powell, Johan L Hans Severens, James W Varni and 3 more

Abstract readValidation Study
In one paragraph

Article in Journal of patient-reported outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

James C MarcusPatient Centered Solutions, IQVIA, Washington, DC, USA.ORCID http://orcid.org/0000-0001-5223-4173
Tiago MaiaPatient Centered Solutions, IQVIA, Porto Salvo, Portugal. tiagomtmaia@gmail.com.ORCID http://orcid.org/0000-0001-5711-8155
Paul WilliamsPatient Centered Solutions, IQVIA, Courbevoie, France.ORCID http://orcid.org/0000-0001-6259-0390
Renata T C YokotaP95 Epidemiology & Pharmacovigilance, Leuven, Belgium.ORCID http://orcid.org/0009-0004-9752-5758
Sofie ArnetorpHealth Economics & Payer Evidence, BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.ORCID http://orcid.org/0009-0004-7624-0091
Timothy A HerringMedical Evidence, Epidemiology, Vaccine & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Wilmington, DE, USA.ORCID http://orcid.org/0000-0002-3475-8616
Sudhir VenkatesanBPM Evidence Statistics, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.ORCID http://orcid.org/0000-0002-2093-5781
Philip A PowellSCHARR, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0003-1169-3431
Johan L Hans SeverensSeverens HTA Consultancy, Venray, Netherlands.ORCID http://orcid.org/0000-0001-9590-0244
James W VarniTexas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0003-4816-4357
Sylvia TaylorMedical Evidence, Vaccine & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.ORCID http://orcid.org/0000-0001-7803-0611
Marieke KrolPatient Centered Solutions, IQVIA, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-6153-0828
John E WareJohn Ware Research Group, Watertown, MA, USA.ORCID http://orcid.org/0000-0002-0744-2149

Funding

AstraZeneca AstraZeneca
6 · The paper itself

Abstract

backgroundMany immunocompromised individuals continue to practice physical distancing behaviors to avoid severe COVID-19 outcomes. To measure the intensity of these physical distancing behaviors, we aimed to develop and validate a standardized metric across age groups: the Physical Distancing Scale for COVID-19 Avoidance (PDS-C19©). METHODOLOGY: PDS-C19 development involved content scoping, initial draft PDS-C19 design phase, and exploratory testing (via asynchronous online forums). Psychometric properties (structural validity, reliability, and construct validity) of the PDS-C19 were evaluated using a random sample of immunocompromised and non-immunocompromised participants (n = 1059) of the EAGLE Study, including adults and children aged 0.5-17 years from the US and UK. Adult caregivers of children aged ≤ 12 years completed a proxy version of the PDS-C19 on their behalf, in addition to providing self-reported responses.

resultsFindings from the two asynchronous forums (n = 23 and n = 22) indicated that the items identified in the scoping phase were relevant and well-understood. As part of the structural validity analysis, item-response distributions, inter-item correlations, and exploratory factor analyses supported a nine-item unidimensional intensity scale. Confirmatory factor analyses reduced the PDS-C19 to seven items (two items were dropped due to high residual correlations or differential item functioning by age). Internal consistency was high (ω = 0.97); convergent validity was good, with high correlations (r

conclusionThe PDS-C19 had acceptable structural and construct validity and high internal consistency, demonstrating its value as a measure of physical distancing to avoid COVID-19 in immunocompromised and non-immunocompromised individuals.

Indexed as

COVID-19Immunocompromised HostPhysical DistancingAdolescentAdultChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedPandemicsPsychometricsReproducibility of ResultsSARS-CoV-2Behavioral assessment scaleClinical outcome assessmentCOVID-19EAGLE StudyPDS-C19Physical distancing

Identifiers

PMID42663898
PMCPMC13525139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.