Evidence map›Paper›PMID 42663801›Full record

ArticleJournal of natural medicines2026

Discovery of four new malabaricane saponins, malabarosides A-D, from the aerial parts of Dysphania ambrosioides with nitric oxide production inhibitory activity.

Phan Van Kiem, Nguyen Thi Viet Ai, Bui Huu Tai, Nguyen Huy Hoang, Phan Thi Thanh Huong, Duong Thi Hai Yen, Do Thi Thao, Nguyen Phuong Thao, Nguyen The Cuong, Bui Van Thanh and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Phan Van KiemInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam. phankiem@vast.vn.ORCID http://orcid.org/0000-0003-0756-6990
Nguyen Thi Viet AiNational Institute of Drug Quality Control, 48 Hai Ba Trung, Cua Nam, Hanoi, Vietnam.
Bui Huu TaiInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Nguyen Huy HoangInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Phan Thi Thanh HuongInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Duong Thi Hai YenInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Do Thi ThaoInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Nguyen Phuong ThaoInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Nguyen The CuongInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Bui Van ThanhInstitute of Biology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Duong Thi DungInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.
Pham Hai YenInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.

Funding

Vietnam Academy of Science and Technology NCXS01.01/26-28
6 · The paper itself

Abstract

The plant Dysphania ambrosioides has long been best known for its traditional use as a medicine to treat worms and other intestinal parasites, as well as for treating wounds. Phytochemical study of the methanol extract of the aerial parts of D. ambrosioides led to the isolation of four undescribed 13α-malabaricane saponins named malabarosides A-D (1-4). Their chemical structures were determined based on extensive spectroscopic analysis, including HR-ESI-MS, 1D and 2D NMR spectra. These compounds moderately inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with IC

Indexed as

AmaranthaceaeDysphania ambrosioidesMalabaricaneMalabarosideNitric oxide inhibitor

Identifiers

PMID42663801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.