Evidence map›Paper›PMID 42663793›Full record

ArticleNatural products and bioprospecting2026

Genome mining guided identification of new furo[3,2-c]pyridones phaeopyridones A-C from the endophytic fungus Phaeobotryon negundinis 12020.

Ke Ye, Jie Shi, Huimin Wu, Shujie Wang, Zexu Lin, Jiale Sun, Yuwei Chen, Bohao Wang, Rongxuan Wang, Chenglin Jiang and 6 more

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In one paragraph

Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Ke YeState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jie ShiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Huimin WuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Shujie WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Zexu LinState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jiale SunState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yuwei ChenNanjing Technology University, Nanjing, 211816, China.
Bohao WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Rongxuan WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Chenglin JiangThe Key Lab for Research & Development of Actinomycete Resources, Yunnan Institute of Microbiology, Yunnan University, Chenggong District, Kunming, 650500, China.
Yi JiangThe Key Lab for Research & Development of Actinomycete Resources, Yunnan Institute of Microbiology, Yunnan University, Chenggong District, Kunming, 650500, China.
Tom HsiangSchool of Environmental Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Bin ZhuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Lixin ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Xueting LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Guoliang ZhuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China. zhuguoliang@ecust.edu.cn.ORCID http://orcid.org/0000-0002-6628-8874

Funding

National Natural Science Foundation of China 32121005National Natural Science Foundation of China 32327801Shanghai Sci-Tech Inno Center for Infection & Immunity SSIII-2024A01Shanghai Sci-Tech Inno Center for Infection & Immunity SSIII-2024A02the 111 Project B18022the National Key Research and Development Program of China 2025YFA0923200
6 · The paper itself

Abstract

Three pairs of new furo[3,2-c]pyridone derivative racemates, named (±)-phaeopyridones A-C (1-3), together with two new compounds, berkeleyamide E (4), and phaeopyranone (5), were isolated from the endophytic fungus Phaeobotryon negundinis 12020, along with three known compounds, (8S,9S)-dihydroisoflavipucine (6), (8S,9R)-dihydroisoflavipucine (7), and sapinopyridione (8), guided by bioinformatics and feature-based molecular networking and fragment-based LC-MS/MS analysis. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses and single-crystal X-ray diffraction. Furthermore, a biosynthetic pathway for compounds 1-3 was proposed, indicating the unique furo[3,2-c]pyridone moiety may be generated by a non-enzymatic intermolecular hemiketal formation reaction. Our research expands the known range of flavipucine alkaloids and highlights the unexplored biosynthetic potential of natural products derived from endophytic fungi.

Indexed as

Endophytic fungiFeature-based molecular networkingFlavipucine alkaloidsFuro[3,2-c]pyridones

Identifiers

PMID42663793
PMCPMC13525150

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