ArticleMikrochimica acta2026
A versatile AuNPs@UiO-66-based electrochemiluminescent immunosensing platform for sensitive detection of talin proteins.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An electrochemiluminescent (ECL) immunosensing strategy developed based on a gold nanoparticle-decorated UiO-66 composite (AuNPs@UiO-66) for the sensitive detection of proteins is reported. Benefiting from the synergistic effect between UiO-66 and AuNPs, the nanocomposite exhibits amplified luminol ECL due to specific surface area, fast electron-transfer, and catalytic activity toward the yielding of reactive oxygen species (ROSs). Meanwhile, the AuNPs provide favorable conditions for antibody immobilization to realize the specific sensing performance. The formation of immune-complexes leads to increasing steric hindrance of probe and interfacial electron-transfer resistance, resulting in decreased ECL emission. Under optimized conditions, the immunosensor for Talin-1 exhibits a linear range of 5-1000 pg·mL
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