ArticleEuropean journal of nuclear medicine and molecular imaging2026
Associations of visceral adipose tissue metabolism with DMN-centered cross-network metabolic expression concordance and cognitive impairment in Alzheimer's disease.
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeVisceral adipose tissue (VAT) has been identified as a risk factor for Alzheimer's disease (AD). This study aimed to investigate the associations between glucose metabolism in VAT and subcutaneous adipose tissue (SAT) with abnormalities in large-scale brain metabolic networks and cognitive impairment in patients with AD.
methodsNinety-eight patients with AD and 51 normal controls (NCs) underwent total-body
resultsCompared with NCs, patients with AD showed significantly increased glucose metabolism in both VAT and SAT, accompanied by reduced metabolic load scores in the DMN, dorsal attention network (DAN), frontoparietal network (FPN), and sensorimotor network (SMN), and lower global DMN-MEC. Correlation analyses within the AD group showed that the DMN metabolic load score was significantly positively correlated with the metabolic load scores of multiple other networks. Furthermore, VAT metabolism was significantly negatively associated with the global DMN-MEC index, whereas SAT metabolism showed no such association. VAT metabolic activity was also negatively correlated with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. In contrast, DMN metabolic load and global DMN-MEC index showed positive associations with cognitive performance.
conclusionThese findings revealed concomitant abdominal adipose tissue metabolic dysfunction and disruption of large-scale brain metabolic network expression in AD. Importantly, higher VAT metabolism was associated with lower global DMN-MEC and poorer cognitive performance.
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