Evidence map›Paper›PMID 42663553›Full record

ArticleTechnology in cancer research & treatment

METTL3-Mediated m6A Modification of COL5A2 Inhibits Ferroptosis Through an IGF2BP3-dependent Mechanism in Gastric Cancer.

Guo Xin, Li Shuang, Guo Yuying, Ji Lina

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Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guo XinDepartment of Digestive Oncology, Shanxi Academy of Medical Sciences; Shanxi Bethune Hospital, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi.ORCID 0000-0001-6635-335X
Li ShuangDepartment of Digestive Oncology, Shanxi Academy of Medical Sciences; Shanxi Bethune Hospital, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi.
Guo YuyingDepartment of Digestive Oncology, Shanxi Academy of Medical Sciences; Shanxi Bethune Hospital, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi.
Ji LinaDepartment of Digestive Oncology, Shanxi Academy of Medical Sciences; Shanxi Bethune Hospital, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionMETTL3, the core enzyme of m6A methylation, influences gastric cancer (GC) progression, but its role in ferroptosis remains unclear. This study investigated the regulatory role of METTL3 in GC ferroptosis and its underlying mechanism via the downstream target gene collagen type V alpha 2 chain(COL5A2).MethodGC cell lines (AGS, MKN-45) and normal GES-1 cells were used. Ferroptosis was induced by erastin and RSL-3. METTL3 overexpression/knockdown models were constructed to assess ferroptosis indicators, including lipid reactive oxygen species(ROS), malondialdehyde(MDA), Fe

Indexed as

AdenosineFerroptosisMethyltransferasesRNA-Binding ProteinsStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceRNA MethylationXenograft Model Antitumor AssaysAdenosineIGF2BP3 protein, humanMethyltransferasesMETTL3 protein, humanN-methyladenosineRNA-Binding ProteinsCOL5A2FAK/MAPK/ERKferroptosisgastric cancerIGF2BP3METTL3

Identifiers

PMID42663553
PMCPMC13527347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.