Evidence map›Paper›PMID 42663512›Full record

ArticleMycoses2026

Genotypes, Fluconazole Tolerance and Virulence Phenotypes of Candida albicans Bloodstream Isolates: A Multilocus Sequence Typing-Based Analysis.

Shang-Yi Lin, Yin-Tse Huang, Ho-Yin Huang, Wei-Chun Hung, Yi-Ting Tseng, Po-Liang Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mycoses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shang-Yi LinGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yin-Tse HuangDepartment of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-8150-7660
Ho-Yin HuangDepartment of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wei-Chun HungDepartment of Microbiology and Immunology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-9487-9025
Yi-Ting TsengDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Po-Liang LuDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-7423-6783

Funding

Kaohsiung Medical University Hospital Research Program KMUH114-4R26Kaohsiung Medical University Research Program KMU-TB114001-2Ministry of Science and Technology, Taiwan NSTC 114-2314-B-037-085-MY2
6 · The paper itself

Abstract

backgroundFluconazole tolerance is an emerging phenotype in Candida albicans bloodstream infections, but its relationship to multilocus sequence typing (MLST) lineages and virulence traits is unclear.

objectivesTo investigate the relationships among MLST genotypes, fluconazole tolerance, and virulence phenotypes in C. albicans bloodstream isolates.

methods179 C. albicans bloodstream isolates collected from three hospitals in southern Taiwan (2013-2020) were evaluated. Fluconazole tolerance was quantified as the fraction of growth within the inhibition zone (FoG

resultsThe cohort exhibited significant fluconazole tolerance with a mean FoG

conclusionsFluconazole tolerance in C. albicans was distributed across diverse lineages, suggesting convergent adaptation. Clade 16 and protease activity were independently associated with tolerance. Given the observed trend toward an association between high tolerance and 14-day mortality, future mechanistic studies and larger clinical outcome studies are warranted.

Indexed as

Antifungal AgentsCandida albicansCandidemiaFluconazoleGenotypeBiofilmsDrug Resistance, FungalHumansMicrobial Sensitivity TestsMultilocus Sequence TypingPhenotypeTaiwanVirulenceAntifungal AgentsFluconazolebiofilmsCandida albicansfluconazolegenetic backgroundMLSTproteasestolerancevirulence

Identifiers

PMID42663512
PMCPMC13523731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.