Evidence map›Paper›PMID 42663505›Full record

ArticleThoracic cancer2026

Decoding Malignant Lung Ground Glass Opacities: A Radiologic-Pathologic Study From Pure to Semi-Solid Lesions.

Alessandro Bonis, Giulia Pagliarini, Vincenzo Verzeletti, Sara Cecchinato, Anna Michielin, Serena Zanardo, Marco De Silvestro, Luigi Lione, Chiara Giraudo, Eleonora Faccioli and 6 more

Abstract read
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In one paragraph

Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessandro BonisThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0001-9422-0597
Giulia PagliariniThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0009-0009-9006-4684
Vincenzo VerzelettiThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0001-7239-1248
Sara CecchinatoUnit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.
Anna MichielinUnit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.
Serena ZanardoThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0009-0003-1020-6862
Marco De SilvestroThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0009-0003-6041-8046
Luigi LioneThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0009-0009-4687-2369
Chiara GiraudoUnit of Advanced Clinical and Translational Imaging, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0003-0924-5883
Eleonora FaccioliThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.
Giorgio CannoneThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.
Marco MammanaThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0003-0885-2403
Alessandro RebussoThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0009-0008-6493-7413
Giovanni Maria ComacchioThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0002-3166-1843
Marco SchiavonThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0001-8780-2011
Andrea Dell'AmoreThoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health-DCTV, University of Padova, Padova, Italy.ORCID https://orcid.org/0000-0002-1384-7441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGround-glass opacities (GGOs) are increasingly detected due to widespread low-dose CT screening for lung cancer. Among them, malignant GGOs (mGGOs) are a clinical challenge. This study aimed to compare the radiological and anatomopathological characteristics of pure and semi-solid mGGOs and to identify radiological predictive factors for consolidation.

methodsA retrospective study was conducted on patients resected due to mGGOs between 2016 and 2023. Patients were classified based on whether initially pure mGGOs remained pure or developed a solid component before surgery. Radiological, pathological, and molecular characteristics were analyzed.

resultsOf 135 patients, 61 (46%) mGGOs became partially solid during surveillance. Semi-solid mGGOs had a higher acinar component (p = 0.038) and larger pathological diameter (20 vs. 18 mm, p = 0.047), while pure mGGOs had a higher lepidic percentage (20% vs. 10%, p = 0.026). STAS and LVI were observed in 25% and 15% of cases. Logistic regression showed pleural contact was protective against consolidation (p = 0.033), while arterial vascularization was predictive of consolidation (p = 0.028). Five-year survival was comparable and satisfactory for both groups (81.7% for pures and 85.5% for semi-solids). Overall, LVI but no STAS was cause of a lower survival expectancy in the entire sample, regardless of consolidation (p = 0.004).

conclusionsBoth pure and semi-solid mGGOs showed precocious pathological and molecular features. Surgical intervention with curative intent, even in pure GGOs, is accompanied by long expected survivals. Vascular features on imaging may help inform surgical decision-making, whereas pathological LVI may have prognostic significance in patients with mGGOs.

Indexed as

Lung NeoplasmsTomography, X-Ray ComputedAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective Studiesadenocarcinomaground‐glass opacitiespathological variablesresectable NSCLC

Identifiers

PMID42663505
PMCPMC13523728

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