Evidence map›Paper›PMID 42663337›Full record

ArticleJACC. Basic to translational science2026

SGLT2-Inhibitors and Molecular Signatures of Aortic Valve Remodeling in Severe Aortic Stenosis: The Valve-AS Study.

Pasquale Paolisso, Lucia Scisciola, Manuela Giovanna Basilicata, Emanuela Salviati, Marta Belmonte, Leen Delrue, Giuseppe Comentale, Pasquale Policastro, Marco Redivo, Linda Piras and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Pasquale PaolissoCardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: pasquale.paolisso@gmail.com.
Lucia ScisciolaDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Manuela Giovanna BasilicataDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Emanuela SalviatiDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Marta BelmonteCardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Leen DelrueCardiovascular Center AZORG, Aalst, Belgium.
Giuseppe ComentaleDepartment of Advanced Biomedical Sciences, University Federico II, Naples, Italy.
Pasquale PolicastroCardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Marco RedivoCardiology Unit, Sant'Andrea University Hospital, Rome, Italy.
Linda PirasCardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Francesco ZitoCardiology Unit, Sant'Andrea University Hospital, Rome, Italy.
Marco ColiCardiology Unit, Sant'Andrea University Hospital, Rome, Italy.
Raffaella MistrulliCardiovascular Center AZORG, Aalst, Belgium; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Rashmi JoshiDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Emanuele GallinoroCardiology Unit, Sant'Andrea University Hospital, Rome, Italy.
Luca BergamaschiCardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy; Unit of Cardiology, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Sant'Orsola-Malpighi Hospital, IRCCS, Bologna, Italy.
Carmine PizziCardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy; Unit of Cardiology, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Sant'Orsola-Malpighi Hospital, IRCCS, Bologna, Italy.
Filip CasselmanCardiovascular Center AZORG, Aalst, Belgium.
Bernard StockmanCardiovascular Center AZORG, Aalst, Belgium.
Giovanna AquinoDepartment of Pharmacy, University of Salerno, Fisciano, Italy; AREA Science Park, Multi-Omics Laboratory Area Sud (LAAS), Baronissi, Salerno, Italy.
Antonio Pio MontellaDepartment of Translation Medical Science, University of Campania "Luigi Vanvitelli" and Monaldi Hospital, Naples, Italy.
Michele TorellaDepartment of Translation Medical Science, University of Campania "Luigi Vanvitelli" and Monaldi Hospital, Naples, Italy.
Marisa De FeoDepartment of Translation Medical Science, University of Campania "Luigi Vanvitelli" and Monaldi Hospital, Naples, Italy.
Emanuele PilatoDepartment of Advanced Biomedical Sciences, University Federico II, Naples, Italy.
Jozef BartunekCardiovascular Center AZORG, Aalst, Belgium.
Eduardo Maria SomellaDepartment of Pharmacy, University of Salerno, Fisciano, Italy; AREA Science Park, Multi-Omics Laboratory Area Sud (LAAS), Baronissi, Salerno, Italy.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, Fisciano, Italy; AREA Science Park, Multi-Omics Laboratory Area Sud (LAAS), Baronissi, Salerno, Italy.
Raffaele MarfellaDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marc VanderheydenCardiovascular Center AZORG, Aalst, Belgium.
Giuseppe PaolissoDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Emanuele BarbatoCardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giovanni MelinaCardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Michelangela BarbieriDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) exerts pleiotropic metabolic and anti-inflammatory effects, but its role in calcific aortic valve stenosis (CAVS) is unclear. In this multicenter prospective study, 83 patients with severe CAVS undergoing surgical aortic valve replacement were stratified by SGLT2i use. Explanted valve tissue and plasma were analyzed using transcriptomics, circulating biomarkers, and metabolomics, including MALDI-MSI. SGLT2i therapy was associated with reduced valvular expression of SGLT1/2, GLUT4, and NHE, increased PPARα, decreased PPARγ, attenuation of inflammatory signaling (lower NF-κB and IL-6), and oxidative stress response (higher SOD2). Extracellular matrix turnover and fibrocalcific remodeling enzymes (MMP-9 and MMP-12) were also reduced. Metabolomic profiling demonstrated distinct clustering, with enrichment of amino acid and redox pathways in SGLT2i users. These findings suggest that SGLT2i therapy is associated with coordinated molecular and metabolic reprogramming of the valvular microenvironment, supporting a potential disease-modifying role in CAVS.

Indexed as

aortic valve remodelingcalcific aortic valve stenosis (CAVS)MALDI-MSImetabolic signaturesomicssodium-glucose cotransporter 2 inhibitor (SGLT2i)

Identifiers

PMID42663337
PMCPMC13749045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.