ArticleObesity (Silver Spring, Md.)2026
Beyond BMI: Genome-Wide Associations of Visceral Fat, Fat Mass, and Fat-Free Mass in Eastern Asian Populations.
Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveBMI is widely used to define obesity and may not capture heterogeneity in body fat distribution. Genetic studies of obesity have largely focused on BMI but not visceral fat and fat-free mass, which is particularly limited in East Asian populations. This study aimed to explore the genetic associations among body composition traits.
methodsWe conducted genome-wide association studies (GWAS) of fat composition traits, including visceral fat, fat mass, and fat-free mass, in 14,121 adults from a population-based biobank. Bioelectrical impedance analysis was used for standardized body composition. GWAS were performed, followed by multinomial logistic regressions for associations across phenotype strata, adjusting for BMI and confounders.
resultsGWAS identified multiple SNPs significantly associated with visceral fat, fat mass, and fat-free mass. A variant within the TTN-rs794727539 was inversely associated with visceral fat and positively associated with fat-free mass, independent of BMI. Additional loci showed trait-specific associations, while many fat-mass-associated variants were attenuated after BMI adjustment, highlighting different genetic regulation of fat distribution.
conclusionsWe found that visceral fat, fat mass, and fat-free mass were governed by partially distinct genetic mechanisms not fully captured by BMI. These results underscore the importance of incorporating fat composition phenotypes into genetic studies in East Asian populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.