Evidence map›Paper›PMID 42663059›Full record

ArticlePharmaceutical biology2026

Profiling of euphane and tirucallane triterpenes from

Mohamed Abakar Maaz, Anita Barta, Dragana Markovic, Simon Singer, Jürg Gertsch, Róbert Berkecz, Peter Waweru Mwangi, Judit Hohmann, Andrea Vasas

Abstract read
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In one paragraph

Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed Abakar MaazInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Anita BartaInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.ORCID 0000-0003-0606-2766
Dragana MarkovicInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Simon SingerInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Jürg GertschInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0003-0978-1555
Róbert BerkeczInstitute of Pharmaceutical Analysis, University of Szeged, Szeged, Hungary.ORCID 0000-0002-9076-2177
Peter Waweru MwangiSchool of Biological Sciences, University of Nairobi, Nairobi, Kenya.
Judit HohmannInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.ORCID 0000-0002-2887-6392
Andrea VasasInstitute of Pharmacognosy, University of Szeged, Szeged, Hungary.ORCID 0000-0002-1818-7702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveThis study aimed to investigate the terpenoid constituents of MATERIALS AND

methodsCompounds were isolated by multistep chromatography and structurally elucidated using HRMS and 1D/2D NMR. Biological activity was assessed against

resultsSix new euphane and tirucallane triterpenes and six known triterpenes were isolated. None were selectively active against DISCUSSION AND

conclusionsOur results indicate that the ergostane triterpene represents an unexplored scaffold for antileukemic drug discovery. Based on an unexpected observation in a cellular

Indexed as

Antineoplastic Agents, PhytogenicEuphorbiaImmunologic FactorsImmunomodulating AgentsLeukemiaPlant ExtractsTriterpenesAnimalsDose-Response Relationship, DrugHL-60 CellsHumansPlant LeavesTrypanosoma cruziU937 CellsAntineoplastic Agents, PhytogenicImmunologic FactorsImmunomodulating AgentsPlant ExtractstirucallaneTriterpenesantileukemicEuphorbia systyloidesimmunomodulatory effecttriterpenesTrypanosoma cruzi

Identifiers

PMID42663059
PMCPMC13528120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.