Evidence map›Paper›PMID 42662998›Full record

ArticleJIMD reports2026

Plasma Lactate Response to a 12-Min Walk Test Is a Poor Diagnostic Biomarker for Mitochondrial Myopathy.

Christine Lando, Tahmina Khawajazada, Jesper Helbo Storgaard, Nanna Scharff Poulsen, John Vissing, Nicoline Løkken

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In one paragraph

Article in JIMD reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christine LandoCopenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark.
Tahmina KhawajazadaCopenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark.
Jesper Helbo StorgaardCopenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark.
Nanna Scharff PoulsenCopenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark.
John VissingCopenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark.
Nicoline LøkkenCopenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark.ORCID https://orcid.org/0000-0002-5494-8484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial myopathy (MM) represents a group with a broad phenotypic spectrum which complicates the diagnostic process. This study investigated whether plasma lactate changes following a 12-min walk test (12MWT) and 20-min recovery could be a diagnostic screening tool for MM. Thirty patients with MM and 19 healthy controls (HC) participated. Total walking distance and heart rate during the test were measured, along with plasma lactate at rest, after exercise, and during recovery. For the latter, we calculated the area under the curve (AUC). The results were compared between groups. MM patients walked shorter (1082 m [994-1143] m vs. 1349 m [1149-1435],

Indexed as

12‐min walk test6‐min walk testdiagnostic screening testmitochondrial myopathyplasma lactaterelative workload

Identifiers

PMID42662998
PMCPMC13521681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.