ArticleJournal of conservative dentistry and endodontics2026
Outcome evaluation of regenerative endodontic therapy using injectable-platelet-rich fibrin and platelet-rich fibrin in nonvital immature permanent teeth: A prospective observational study.
Article in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pulp necrosis in an immature permanent tooth disrupts root development, often treated with calcium hydroxide or Mineral Trioxide Aggregate (MTA) apexification, however, these approaches do not improve structural integrity of teeth. Regenerative endodontic therapy (RET) promotes root maturation, with blood clot and platelet-rich fibrin (PRF) commonly used as a scaffold. Injectable PRF (i-PRF) may offer enhanced biological properties. Aim: This study aimed to compare clinical and radiographic outcomes of RET using i-PRF and PRF in nonvital immature permanent teeth. Settings and Design: Department of Conservative Dentistry and Endodontics, Department of Paediatric Dentistry, Government Dental College, Thiruvananthapuram. Prospective Observational Study. Materials and Methods: Thirty-eight patients undergoing RET were allocated into two groups: Group I (i-PRF, Results: Group I demonstrated a higher success rate (100%) and significantly greater reduction in PAI scores ( Conclusion: i-PRF demonstrated superior periapical healing and overall treatment outcomes compared to PRF, whereas both groups showed comparable effects on root development. These findings suggest that i-PRF may represent a promising biological scaffold for regenerative endodontic treatment of immature permanent teeth.
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