ArticleChemical science2026
Time-resolved image-guided Type-I photosensitization using a delayed fluorescent emitter.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
The development of next-generation image-guided thermally activated delayed fluorescent photosensitizers requires high quantum yield, organelle specificity, and low oxygen dependence to enable effective photodynamic therapy. A subtle balance between the opposing requirements of strong radiative transition for high-contrast imaging and efficient nonradiative decay for reactive oxygen species generation remains a key challenge for time-resolved image-guided photodynamic therapy. In this study, we present a lipid droplet (LD) targeting delayed fluorescent probe, based on substituted keto-coumarin, DCBP, and its water-dispersible nanoparticles. DCBP in solution and aqueous dispersions exhibits long-lived emission and possesses an optimum excited-state oxidation potential, promising for time-resolved image-guided Type-I photosensitization. The intrinsic hydrophobicity of DCBP nanoparticles promotes specificity towards lipid droplets, exhibiting pronounced phototoxicity under normoxic and hypoxic conditions
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