Evidence map›Paper›PMID 42662793›Full record

ArticleClinical neurophysiology practice2026

Spastic co-contraction: A misdirected central command.

Jean-Michel Gracies, Robert J Kahoud, Maria Vinti, Simon C Gandevia, David Burke, Maud Pradines

Abstract read
In one paragraph

Article in Clinical neurophysiology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jean-Michel GraciesNeuroscience Research Australia and University of New South Wales, Randwick, NSW, Australia.
Robert J KahoudPediatrics Department, Mayo Clinic Rochester, United states.
Maria VintiUniv. Limoges, HAVAE, UR 20217, F-87000 Limoges, France.
Simon C GandeviaNeuroscience Research Australia and University of New South Wales, Randwick, NSW, Australia.
David BurkeDepartment of Neurology, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.
Maud PradinesUR 7377 BIOTN, Université Paris-Est Créteil (UPEC), F-94000 Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Antagonist co-contraction triggered by voluntary agonist command in spastic paresis is poorly understood. Using an isometric ankle paradigm designed to minimize movement-related stretch reflexes, we aimed to characterize the severity, modulation, and neurophysiological origin of spastic co-contraction. Methods: Thirteen subjects with chronic hemi/paraparesis ( Results: Antagonist co-contraction occurred in all limbs during dorsi- and plantar flexor efforts. Its severity increased from submaximal to maximal efforts, whether in knee flexion ( Conclusions: Spastic co-contraction likely reflects misdirected descending supraspinal command, potentiated by stretch-related peripheral afferent signals.

Indexed as

HemiparesisIsometric contractionSpastic co-contractionSpasticity

Identifiers

PMID42662793
PMCPMC13520632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.