Evidence map›Paper›PMID 42662756›Full record

ArticleACS omega2026

Modulation of Donepezil Release Through Hydrophobic Ion- Pairing with Oleic Acid in Liquid Crystalline Nanodispersions for Transdermal Delivery.

Priscila Pires da Silva, Victor Cavalcanti Marques, Lorena Kelly Santiago Ramos, José Dias de Souza Filho, Renato Ferreira de Freitas, Marina Guimarães Carvalho Machado, Marcus Vinícius Cangussu Cardoso, Flávia de Souza Marques, Paula Melo de Abreu Vieira, Leonardo da Silva Araújo and 3 more

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Priscila Pires da SilvaGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Victor Cavalcanti MarquesGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Lorena Kelly Santiago RamosGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
José Dias de Souza FilhoGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Renato Ferreira de FreitasGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Marina Guimarães Carvalho MachadoGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Marcus Vinícius Cangussu CardosoGraduate Program in Biotechnology, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-5124-0432
Flávia de Souza MarquesGraduate Program in Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Paula Melo de Abreu VieiraGraduate Program in Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-7033-7686
Leonardo da Silva AraújoDepartment of Physics, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.
Jaqueline Dos Santos SoaresDepartment of Physics, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-2674-5791
Jacqueline de SouzaGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-0869-023X
André Luís Morais RuelaGraduate Program of Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, UFOP, Ouro Preto 35400-000, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-1258-8705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precursor liquid crystals based on unsaturated monoglycerides, with or without oleic acid (OA), exhibited anisotropy characteristic of an inverse hexagonal phase. Donepezil-loaded liquid crystalline nanodispersions (LCNs) were produced by sonication and exhibited encapsulation efficiencies of 91.3-97.9%, with the OA-containing formulation (LCN-2) displaying a smaller particle size (183.0 ± 1.5 nm), lower polydispersity (0.183 ± 0.006), and improved colloidal stability over 90 days. NMR (

Identifiers

PMID42662756
PMCPMC13520556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.