Evidence map›Paper›PMID 42662745›Full record

ArticleACS omega2026

Mining of Novel Human DPP-IV-Targeting Tripeptides through Multicomputational Screening and In Vitro Validation for Diabetes Therapy.

James V Lavilla, Francis Kirby B Burnea, Hironobu Hojo, Changge Guan, Charlie A Lavilla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James V LavillaDepartment of Chemistry, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Iligan City, Lanao del Norte 9200, Philippines.ORCID https://orcid.org/0009-0006-0175-3866
Francis Kirby B BurneaDepartment of Chemistry, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Iligan City, Lanao del Norte 9200, Philippines.
Hironobu HojoInstitute for Protein Research, The University of Osaka, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID https://orcid.org/0000-0003-0916-1233
Changge GuanMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6243, United States.ORCID https://orcid.org/0000-0003-2531-6821
Charlie A LavillaDepartment of Chemistry, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Iligan City, Lanao del Norte 9200, Philippines.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of peptide-based hDPP-IV inhibitors. Herein, an integrated multicomputational screening strategy was employed to successfully mine novel hDPP-IV inhibitory tripeptides. Among the screened candidates, FAW exhibited the highest inhibitory activity, with an IC

Identifiers

PMID42662745
PMCPMC13520525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.