Evidence map›Paper›PMID 42662721›Full record

ArticleACS omega2026

From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1‑G

Bianca Fiorillo, Federica Moraca, Francesco Saverio Di Leva, Valentina Sepe, Stefano Fiorucci, Vittorio Limongelli, Angela Zampella, Bruno Catalanotti

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianca FiorilloDepartment of Pharmacy, University of Naples "Federico II", via D. Montesano, 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-3025-5157
Federica MoracaDepartment of Pharmacy, University of Naples "Federico II", via D. Montesano, 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-1077-1971
Francesco Saverio Di LevaDepartment of Pharmacy, University of Naples "Federico II", via D. Montesano, 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-2294-0656
Valentina SepeDepartment of Pharmacy, University of Naples "Federico II", via D. Montesano, 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-0169-4441
Stefano FiorucciDepartment of Medicine and Surgery, University of Perugia, Piazza L. Severi, 06132 Perugia, Italy.
Vittorio LimongelliFaculty of Biomedical Sciences, Euler Institute, Università della Svizzera italiana (USI), via G. Buffi, 13, CH-6900 Lugano, Switzerland.ORCID https://orcid.org/0000-0002-4861-1199
Angela ZampellaDepartment of Pharmacy, University of Naples "Federico II", via D. Montesano, 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-6170-279X
Bruno CatalanottiDepartment of Pharmacy, University of Naples "Federico II", via D. Montesano, 49, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-7532-6959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) is a key mediator of bile acid signaling, exerting its physiological effects through coupling with the stimulatory G protein (G

Identifiers

PMID42662721
PMCPMC13520505

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.