ArticleJournal of conservative dentistry and endodontics2026
Targeted detection and antimicrobial susceptibility of common pathogens of failed root canal treatments: A cross-sectional study.
Article in Journal of conservative dentistry and endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pathogens persisting in the root canals lead to endodontic treatment failure. Understanding their prevalence and antimicrobial susceptibility is essential for improving disinfection and treatment outcomes. Objective: To estimate the prevalence of five specific pathogens in failed root canal treatment cases using both culture-based and molecular methods and to evaluate the association between pathogen detection and clinical/radiographic findings and assess the antimicrobial susceptibility of the isolates. Methodology: One hundred samples were collected using the absorbent paper point method and analyzed using culture and multiplex quantitative polymerase chain reaction (qPCR) for the detection of Results: Detection rates were 29% by culture and 82% by qPCR, with Conclusion: Failed root canal treatments demonstrated a high prevalence of persistent pathogens, which are better detected by molecular methods. Observed antimicrobial resistance (AMR), particularly to conventional intracanal medicaments, highlights the growing concern of AMR in endodontic infections and the need for better disinfection strategies.
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