Construction of a dual-compartment hydrogel by protein-based triblock copolymer for the

Xiaoxi Chang, Yiran Qian, Tuo Zhang, Jiachen Zang, Chenyan Lv, Ming Du, Guanghua Zhao

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoxi ChangCollege of Food Science & Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing, 100083, China.

Yiran QianCollege of Food Science & Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing, 100083, China.

Tuo ZhangCollege of Food Science & Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing, 100083, China.

Jiachen ZangCollege of Food Science & Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing, 100083, China.

Chenyan LvCollege of Food Science & Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing, 100083, China.

Ming DuSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China.

Guanghua ZhaoCollege of Food Science & Nutritional Engineering, Beijing Key Laboratory of Functional Food from Plant Resources, China Agricultural University, Beijing, 100083, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naturally occurring volatile bioactives, such as allyl isothiocyanate (AITC), represents a class of potent antimicrobial candidates, yet their clinical translation is severely hindered by inherent volatility and mucosal irritation. On the other hand, the prevalent extracellular acidification characteristic of inflammatory environments provides a unique pathological trigger for designing non-antibiotic therapies. Bioinspired by botanical defense systems, we constructed a mildly-acidic-responsive dual-compartment hydrogel system using a genetically programmed ABC-type protein triblock copolymer. This platform integrates a pH-responsive ferritin subunit (A block) for substrate (allyl glucosinolate, GS) encapsulation, a fibrous tropomyosin subunit (B block) for enzyme (myrosinase) hosting, and a His-tag (C block) for metal-ion coordinated cross-linking. Our designed dry powder microgels, delivered via tracheal infiltration, can be strategically deposited throughout the respiratory tract. Upon rehydration in the acidic microenvironment of inflamed lungs, the hydrogel triggers the

Indexed as

Dual-compartment hydrogelInflamed environmentsMildly-acidic-responsiveProtein triblock copolymerVolatile bioactives

Identifiers

PMID42662606

DOI10.1016/j.mtbio.2026.103578

PMCPMC13521224

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.