Evidence map›Paper›PMID 42662550›Full record

ArticleiScience2026

Brain assembloids reveal efficacy and off target effects in high grade glioma brain cancer.

Farhana Amy Sarker, Yuyan Chen, Victoria Prior, Sam Bax, Louise Orcheston-Findlay, Tom Grundy, Thuvarahan Jegathees, Robert Utama, Martin Engel, Tristan Rawling and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Farhana Amy SarkerFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Yuyan ChenFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Victoria PriorFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Sam BaxFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Louise Orcheston-FindlayChildren's Cancer Research Unit, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia.
Tom GrundyFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Thuvarahan JegatheesFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Robert UtamaInventia Life Science Pty Ltd., Sydney, NSW, Australia.
Martin EngelInventia Life Science Pty Ltd., Sydney, NSW, Australia.
Tristan RawlingSchool of Mathematical and Physical Sciences, University of Technology, Sydney, NSW 2015, Australia.
Yassir Al ZubaidiPharmacogenomics and Drug Development Group, Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.
Michael MurrayPharmacogenomics and Drug Development Group, Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.
Geraldine Margaret O'NeillFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-invasive therapies may limit damage to healthy brain tissue caused by invading high-grade glioma (HGG) cells. However, the actin machinery that drives invasion is shared by cancer and normal cells, and therefore, there is a risk of on-target, off-tumor side effects. We compared omega 3 polyunsaturated fatty acid epoxide analog

Indexed as

anti-invasive therapyhigh grade gliomaorganoid co-culturesside effects

Identifiers

PMID42662550
PMCPMC13521100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.