Evidence map›Paper›PMID 42662548›Full record

ArticleACS omega2026

Discovery of Bis-Thiourea Derivatives as Human DNA Topoisomerase IIα Inhibitors with Potent Anticancer Effects.

Sahachai Sabuakham, Sarunya Kitdumrongthum, Sutita Nasoontorn, Chaiwat Monmai, Chutima Talabnin, Norie Araki, Atit Silsirivanit, Thanyada Rungrotmongkol, Arthit Chairoungdua, Ratchanok Pingaew and 1 more

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sahachai SabuakhamDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Sarunya KitdumrongthumInstitute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.
Sutita NasoontornDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Chaiwat MonmaiDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Chutima TalabninSchool of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Norie ArakiDepartment of Tumor Genetics and Biology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Atit SilsirivanitDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID https://orcid.org/0000-0002-5777-3843
Thanyada RungrotmongkolCenter of Excellence in Structural and Computational Biology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Arthit ChairoungduaDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Ratchanok PingaewDepartment of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.ORCID https://orcid.org/0000-0003-4977-5854
Panupong MahalapbutrDepartment of Biochemistry, Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID https://orcid.org/0000-0003-4389-334X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for their Topo IIα inhibitory activity and anticancer potential using

Identifiers

PMID42662548
PMCPMC13519922

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.