Evidence map›Paper›PMID 42662476›Full record

ArticleCase reports in transplantation2026

Recurrent Cryptogenic Ulcerative Tracheobronchitis 6 Years After Lung Transplantation: Case Report.

Samuel Brookes, Paroma Sarkar, Thomas Crowhurst, Phan Nguyen, Aeneas Yeo, Kate D Lynch, Helen Whitford, Mark Holmes, Chien-Li Holmes-Liew

Abstract read
In one paragraph

Article in Case reports in transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel BrookesDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.ORCID https://orcid.org/0009-0006-8429-7527
Paroma SarkarDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.
Thomas CrowhurstSchool of Medicine, University of Adelaide, Adelaide, South Australia, Australia, adelaide.edu.au.
Phan NguyenDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.ORCID https://orcid.org/0000-0002-8573-3574
Aeneas YeoDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.ORCID https://orcid.org/0000-0002-7122-3725
Kate D LynchSchool of Medicine, University of Adelaide, Adelaide, South Australia, Australia, adelaide.edu.au.ORCID https://orcid.org/0000-0001-7748-2165
Helen WhitfordDepartment of Respiratory Medicine, Townsville University Hospital, Townsville, Queensland, Australia.
Mark HolmesDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.
Chien-Li Holmes-LiewDepartment of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tracheobronchitis is an uncommon pattern of airway disease and is typically caused by infection, inhalation injury, infiltrative disorders and more rarely, systemic autoimmune disease. Rarer again is the development of bronchial webbing following tracheobronchitis. The underlying aetiology is usually identified through biopsy, culture or a detailed clinical history. We present a case of cryptogenic ulcerative tracheobronchitis with bronchial webbing being successfully managed by bilateral lung transplantation that has, however, been complicated by recurrence. Case Presentation: In 2019, Crowhurst et al. detailed the case of a patient who presented with dyspnoea and haemoptysis. Bronchoscopy revealed ulcerative tracheobronchitis and he subsequently formed recurrent web-like stenoses of the central bronchi, leading to rapidly progressive type 2 respiratory failure; he received bilateral sequential lung transplantation for definitive management. At the time of transplant, the presumed diagnosis was an inhalation injury that occurred while travelling in Vietnam, or exposure to the organophosphate pesticide Malathion several days prior. The explanted lung histology revealed ulcerating bronchitis with intense histiocytic infiltrates, bronchial luminal fibrosis and obstruction with scant, poorly formed granulomas. The patient thrived with stable lung function and had minimal complications initially post-transplantation. However, 6 years after lung transplantation and without re-exposure, the patient re-developed ulcerative tracheobronchitis, which shared similar histopathologic features to airway involvement of Crohn's disease. Gastrointestinal or other organ system involvement of Crohn's disease was not established despite extensive investigations. A decision for phenotypic treatment with the TNF- Conclusion: This is the first case documented in the literature of ulcerative tracheobronchitis followed by intense bronchial web-like stenoses caused by an unspecified autoimmune disease, treated by bilateral lung transplantation. The disease recurred after 6 years and responded to phenotypic management with the TNF-

Indexed as

bilateral sequential lung transplantationcase reportCrohn’s diseaseinfliximabtracheobronchitis

Identifiers

PMID42662476
PMCPMC13519885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.