Evidence map›Paper›PMID 42662404›Full record

ArticleiScience2026

RFC5 and STAT3 form a transcriptional complex to drive NSCLC progression via c-Myc.

Jinhua Yan, Tao Yi, Wentao Tian, Jinzheng Wu, Rongji Yu, Shumiao Zhang, Zekun Cheng, Xiaotang Di, Hao Jiang, Doudou Wen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jinhua YanDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Tao YiDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.
Wentao TianDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410028, China.
Jinzheng WuDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Rongji YuDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.
Shumiao ZhangBeijing Milu Ecological Research Center, Beijing 100076, China.
Zekun ChengDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Xiaotang DiDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.
Hao JiangDepartment of Biomedical Informatics, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.
Doudou WenDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.
Shubing ZhangDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC), a leading cause of cancer death worldwide, is often characterized by late diagnosis and treatment resistance, which adversely affect patient prognosis. This study identified replication factor C subunit 5 (RFC5) as a critical oncoprotein in NSCLC progression. Single-cell transcriptomic analysis of multi-stage NSCLC tissues revealed

Indexed as

GATA3NSCLCRFC5STAT3/c-Myc pathwaytranscriptional activation

Identifiers

PMID42662404
PMCPMC13520619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.