ArticleBioinformation2026
Hybridization-based gold nanoprobe assay for the detection of candidemia in ICU patients - A novel method.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candidemia is a life-threatening infection in ICU patients, with mortality rates of 35-75%, yet current diagnostic methods such as blood culture and conventional Polymerase chain reaction (PCR) lack the sensitivity required for timely detection. Therefore, it is of interest to address this unmet diagnostic need, we developed a hybridization-based gold nanoprobe (AuNP) colorimetric assay for the direct detection of Candida DNA from 3 ml EDTA blood samples. AuNPs were functionalized with Candida-specific thiol-modified oligonucleotide probes using a modified salt-aging process and target DNA hybridization was performed at 56°C followed by visual colour assessment. The assay demonstrated 76% sensitivity, significantly outperforming conventional PCR at 24%, with positive results showing a distinct red-to-purple colour shift and a detection limit of 10 ng/µL. This rapid, low-cost, naked-eye-readable method using UV-Vis spectroscopy is particularly suitable for resource-limited ICU settings, offering a practical tool for earlier candidemia diagnosis and improved clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.