Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth.

Setu Kalaria, Rajsundar T, Pradnya Jadhav, Divya B M, Abdullah Tamboli, Kushal Gajendra Shinde

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Setu KalariaDepartment of Conservative Dentistry and Endodontics, AMC Dental College, Khokhra, Ahmedabad, India.

Rajsundar TDepartment of periodontology, Tamil Nadu government dental college and hospital, Satellite peripheral unit, Tambaram, India.

Pradnya JadhavDepartment of Public Health Dentistry, Government Dental College and Hospital, Chhatrapati Sambhajinagar, India.

Divya B MDepartment of Public Health Dentistry, DAPM RV Dental College, Bangalore, India.

Abdullah TamboliDepartment of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be university) Dental college and hospital, Sangli, India.

Kushal Gajendra ShindeDepartment of Public health dentistry, CSMSS Dental College, Chhatrapati Sambhajinagar, India.

Funding

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6 · The paper itself

Abstract

Management of immature permanent teeth with pulp necrosis remains a clinical challenge due to incomplete root development and limitations of conventional endodontic approaches. Therefore, it is of interest to evaluate the clinical and radiographic efficacy of regenerative endodontic procedures using platelet-rich fibrin compared with mineral trioxide aggregate apexification in 40 immature necrotic teeth. Patients were randomly allocated into two groups and assessed clinically and radiographically using periapical radiographs and CBCT at 3, 6 and 12 months. The platelet-rich fibrin group demonstrated significantly greater improvement in root length, dentinal wall thickness and apical closure compared to the apexification group, with higher clinical success rates. Regenerative endodontic procedures using platelet-rich fibrin appear to be more effective in promoting root maturation and periapical healing in immature necrotic teeth.

Indexed as

apexificationimmature necrotic teethperiapical healingplatelet-rich fibrin (PRF)Regenerative endodonticsroot maturation

Identifiers

PMID42662295

DOI10.6026/973206300222811

PMCPMC13519410

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