Evidence map›Paper›PMID 42662249›Full record

ArticleBioinformation2026

A comparative histochemical evaluation of tissue biomarkers in normal and pathological specimens: A retrospective study.

Amit Kumar Srivastava, Aishwarya Srivastava, Rohini Srivastava, Prabha Verma, Jyoti Batra, Yogesh Yadav

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Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Amit Kumar SrivastavaDepartment of Anatomy, Government Medical College, Datia, Madhya Pradesh, India.
Aishwarya SrivastavaDepartment of Biochemistry, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India.
Rohini SrivastavaDepartment of Pathology, Naraina Medical College and Research Centre, Kanpur, Uttar Pradesh, India.
Prabha VermaDepartment of Biochemistry, GSVM Medical College, Kanpur, Uttar Pradesh, India.
Jyoti BatraDepartment of Central Research Facility, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India.
Yogesh YadavDepartment of Anatomy, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh, India.

Funding

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6 · The paper itself

Abstract

Differences in histochemical biomarker expression between normal and pathological tissues remain inadequately characterized. Therefore, it is of interest to evaluate histochemical expression patterns of selected biomarkers in normal and pathological tissue samples. Hence, eighty archived specimens (40 normal and 40 pathological) were analyzed using histochemical staining and semi-quantitative scoring over two years. Pathological tissues showed higher staining intensity and altered distribution patterns, indicating changes in cellular metabolism and extracellular matrix composition. Thus, we show distinct biomarker expression patterns in diseased tissues, supporting their diagnostic and prognostic relevance.

Indexed as

Histochemistrynormal tissuepathological specimensretrospective studytissue biomarkers

Identifiers

PMID42662249
PMCPMC13519417

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