Evidence map›Paper›PMID 42662190›Full record

ArticleACS omega2026

Computational Pipeline Reveals Nature's Untapped Reservoir of Halogenating Enzymes.

Judit Szenei, Ashleigh Burke, Anne Liong, Aleksandra Korenskaia, April L Lukowski, Nadine Ziemert, Pablo I Nikel, Pedro N Leão, Bradley S Moore, Tilmann Weber and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Judit SzeneiThe Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.
Ashleigh BurkeCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0001-9352-4265
Anne LiongInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos 4450-208, Portugal.
Aleksandra KorenskaiaTranslational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tübingen 72074, Germany.
April L LukowskiCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0003-4865-0910
Nadine ZiemertTranslational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen, Tübingen 72074, Germany.ORCID https://orcid.org/0000-0002-7264-1857
Pablo I NikelThe Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0002-9313-7481
Pedro N LeãoInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos 4450-208, Portugal.ORCID https://orcid.org/0000-0001-5064-9164
Bradley S MooreCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-4652-1253
Tilmann WeberThe Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0002-8260-5120
Kai BlinThe Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0003-3764-6051

Funding

Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
NIGMS NIH HHS R01 GM085770
6 · The paper itself

Abstract

Microbial halogenated natural products (hNPs) hold ecological, agricultural, and biomedical relevance. The hNP-producing potential of an organism can be assessed by the precise prediction of halogenating enzymes, yet detailed annotations of halogenases are often missing from genomic and metagenomic data. We created a manually curated database (https://halogenases.secondarymetabolites.org/) containing information on the halide specificity, role, and position of verified catalytic residues and the results of mutagenesis studies of more than 120 experimentally validated or

Identifiers

PMID42662190
PMCPMC13519999

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.