Evidence map›Paper›PMID 42662187›Full record

ArticleNeurotrauma reports

Structural Myelin Mapping in Individuals with a History of Head Injury.

Erica Howard, Jessica Cloud, Ann J Lee, Nicole Saltiel, Scott M Hayes, Jasmeet P Hayes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erica HowardPsychology Department, The Ohio State University, Columbus, Ohio, USA.
Jessica CloudPsychology Department, The Ohio State University, Columbus, Ohio, USA.
Ann J LeePsychology Department, The Ohio State University, Columbus, Ohio, USA.
Nicole SaltielPsychology Department, The Ohio State University, Columbus, Ohio, USA.
Scott M HayesPsychology Department, The Ohio State University, Columbus, Ohio, USA.
Jasmeet P HayesPsychology Department, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-5157-0666

Funding

Contributions of modifiable physical attributes to cognitive and brain agingR01AG068882 · NIA · OHIO STATE UNIVERSITY · PI HAYES, SCOTT M · 2021 to 2025
$3.2M
Neuroimaging and Molecular Markers of AD and Neurodegenerative Disease after ConcussionR01AG058822 · NIA · OHIO STATE UNIVERSITY · PI Jasmeet Pannu Hayes · 2019 to 2026
$2.7M
NIA NIH HHS R01 AG058822NIA NIH HHS R01 AG068882
6 · The paper itself

Abstract

Head injury has emerged as a significant environmental risk factor for dementia. Demyelination, defined as the loss of the fatty protective layer surrounding axons, may be associated with neurodegenerative processes following head injury, especially in cortical regions. Although many neuroimaging studies have investigated demyelination in deep subcortical white matter tracts following head injury, these methods do not readily capture myelinated axons that also extend to the cortical surface. To address this gap, the present study used a structural neuroimaging method (T1-weighted [T1w]/T2-weighted [T2w] ratio) as a proxy measure for intracortical myelin content and related these values to history of traumatic brain injury (TBI) and/or repetitive head impacts (RHIs). The sample included 73 older adults (42% male; mean age = 64.8 years; range: 51-86 years) categorized based on TBI (

Indexed as

ageaxonal injurycortical myelinhuman studiesMRIrepetitive head impactstraumatic brain injury

Identifiers

PMID42662187
PMCPMC13519203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.