Evidence map›Paper›PMID 42662147›Full record

ArticleEuropean journal of radiology open2026

Utility of intracellular enhancement for improving hepatic lesion visibility at gadoxetic acid-enhanced hepatobiliary-phase MRI.

Shogo Maeda, Yuko Nakamura, Toru Higaki, Takashi Nishihara, Masahiro Takizawa, Yoshitaka Bito, Hirokazu Asaka, Kenji Kodakari, Dara Fonseca, Shota Kondo and 6 more

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Article in European journal of radiology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shogo MaedaDiagnostic Radiology, Hiroshima University, Japan.
Yuko NakamuraDiagnostic Radiology, Hiroshima University, Japan.
Toru HigakiDiagnostic Radiology, Hiroshima University, Japan.
Takashi NishiharaFUJIFILM Corporation, Japan.
Masahiro TakizawaFUJIFILM Corporation, Japan.
Yoshitaka BitoFUJIFILM Corporation, Japan.
Hirokazu AsakaFUJIFILM Corporation, Japan.
Kenji KodakariDepartment of Radiology, Hiroshima University Hospital, Japan.
Dara FonsecaDiagnostic Radiology, Hiroshima University, Japan.
Shota KondoDiagnostic Radiology, Hiroshima University, Japan.
Yukiko HondaDiagnostic Radiology, Hiroshima University, Japan.
Yuji AkiyamaDepartment of Radiology, Hiroshima University Hospital, Japan.
Tomokazu KawaokaDepartment of Gastroenterology, Hiroshima University, Japan.
Masataka TsugeDepartment of Gastroenterology, Hiroshima University, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University, Japan.
Kazuo AwaiDiagnostic Radiology, Hiroshima University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the utility of the intracellular enhancement (ICE) technique that suppresses extracellular signal component for shortening the gadoxetic acid (EOB)-enhanced hepatobiliary-phase (HBP) delay time while maintaining lesion visibility. Methods: In this prospective study, patients who underwent EOB-enhanced MRI were screened and those with HBP hypointense hepatic lesions were included. HBP images were acquired at 10 and 20 min post-EOB injection, with and without ICE (i Results: Eighty-one patients were included. Overall image quality was significantly worse with ICE at both 10- and 20-min HBP (10 min: mean 3.8 vs 3.1; 20 min: 4.0 vs 3.3; both p < 0.01). There was no significant difference in the CR between i Conclusion: ICE has the potential to reduce delay time without compromising lesion visualization; however, further studies with larger sample size.

Indexed as

Contrast mediaGd-EOB-DTPAImage enhancementLiver neoplasmsMagnetic resonance imaging

Identifiers

PMID42662147
PMCPMC13519261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.