Hydroxyapatite-mineralized metal-organic frameworks as sonosensitizer modulate tumor microenvironment to potentiate high-intensity focused ultrasound therapy.

Xiaomei Xie, Qi Wang, Hanlin Song, Hong You, Song Peng, Wei Tang, Huanan Li

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Xiaomei XieDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Qi WangDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Hanlin SongDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Hong YouDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Song PengDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Wei TangDepartment of Radiology, Women and Children's Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Huanan LiDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-intensity focused ultrasound (HIFU) has emerged as a game-changing breast-conserving therapeutic modality owing to its dual functions of non-invasive tumor ablation and immunity activation. However, its low focal gain in the target region results in residual tumor tissue after ablation. Inspired by the exceptional acoustic response of bone tumor to HIFU, we developed bone-derived hydroxyapatite (HA)-mineralized metal-organic frameworks (designated as AZSH MOFs) as sonosensitizer that co-encapsulated Zn

Indexed as

Breast cancerHIFUImmunotherapyMetal-organic frameworksSonosensitizer

Identifiers

PMID42662100

DOI10.1016/j.mtbio.2026.103562

PMCPMC13519626

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.