ArticleBlood vessels, thrombosis & hemostasis2026
Increased VWF-to-ADAMTS13 ratio is associated with large cerebral white matter hyperintensities.
Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin motif repeats 13) cleaves highly prothrombotic high molecular weight multimers of von Willebrand factor (VWF). Elevated VWF and low ADAMTS13 activity are associated with ischemic stroke but the association with cerebral white matter hyperintensities (WMH), which are associated with the risk of stroke and mortality, has never been studied. We investigated whether the ratio of VWF antigen to ADAMTS13 activity (VWF-to-ADAMTS13 ratio) is associated with the presence of any WMH or large WMH (≥3 mm) in the Genetic Study for Atherosclerosis Risk cohort. A total of 287 participants with completed brain magnetic resonance imaging had available samples for measurement of VWF antigen and ADAMTS13 activity. Median (interquartile range [IQR]) VWF-to-ADAMTS13 ratio was higher in those with WMH than in those without WMH (0.623 [IQR, 0.434-0.926] vs 0.509 [IQR, 0.373-0.804];
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