Evidence map›Paper›PMID 42662063›Full record

ArticleESMO gastrointestinal oncology2026

Structured surveillance in Lynch syndrome: effectiveness, limitations, and unmet needs.

A Dardenne, R Cohen, C Evrevin, C Duros, N Basset, P Cervera, J H Lefevre, T Germain, C Lepillier, N Chabbert-Buffet and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESMO gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

A DardenneDepartment of Medical Genetics, Sorbonne University, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
R CohenMicrosatellite Instability and Cancers Research Laboratory, INSERM and Sorbonne University, Centre de Recherche Saint-Antoine, Paris, France.
C EvrevinDepartment of Medical Genetics, Sorbonne University, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
C DurosOncogenetics Unit, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
N BassetDepartment of Medical Genetics, Sorbonne University, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
P CerveraDepartment of Pathology, Sorbonne University, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
J H LefevreMicrosatellite Instability and Cancers Research Laboratory, INSERM and Sorbonne University, Centre de Recherche Saint-Antoine, Paris, France.
T GermainDepartment of Urology, Sorbonne University, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
C LepillierDepartment of Gynecology, Sorbonne University, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
N Chabbert-BuffetDepartment of Gynecology, Sorbonne University, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
T AndréDepartment of Medical Genetics, Sorbonne University, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
X DraySorbonne University, Center for Digestive Endoscopy, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Y ParcDepartment of Digestive Surgery, Sorbonne University, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lynch syndrome confers a high lifetime risk of multiorgan cancers. Although colorectal surveillance is well established, prospective data on cancer incidence and adherence to structured multiorgan follow-up and surveillance recommendations remain limited. Materials and methods: We retrospectively analyzed prospectively collected data from 517 individuals carrying a pathogenic or likely pathogenic variant in a mismatch repair gene at a single specialized French center. All patients underwent structured surveillance, including regular colonoscopy and organ-specific follow-up according to national guidelines. Cancer incidence rates, tumor distribution, and modes of detection (asymptomatic versus symptomatic) were assessed over the follow-up. Results: Over 4827 person-years, 201 cancers were diagnosed (annual cancer incidence 4.16%, 95% confidence interval 3.59-4.74). Colorectal cancer was most frequent (41.8%), followed by urinary tract (11.9%) and skin cancers. Among guideline-surveilled organs ( Conclusions: Despite structured, multiorgan surveillance, patients with Lynch syndrome exhibit high cancer incidence and broad tumor distribution. Although current protocols enable early detection for several organs, a substantial proportion of cancers occur outside existing recommendations. These findings support follow-up in dedicated coordination centers and may inform the selective expansion of surveillance strategies to additional high-risk organs.

Indexed as

colorectal cancergastrointestinalLynch syndromemismatch repair genessurgerysurveillance

Identifiers

PMID42662063
PMCPMC13519071

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.