Evidence map›Paper›PMID 42662053›Full record

ArticleiMeta2026

Environmental chemicals and the tumor immune microenvironment.

Tongtong Zhang, Yanxia Hu, Weiran Zhang, Yang Jin, Chaoyang Sun, Afshin Samali, Shunqing Xu, Xia Sheng

Abstract read
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tongtong ZhangInstitute of Biomedical Research, School of Life and Health Sciences Hainan University Haikou China.ORCID https://orcid.org/0009-0001-1566-0787
Yanxia HuInstitute of Biomedical Research, School of Life and Health Sciences Hainan University Haikou China.ORCID https://orcid.org/0000-0002-1815-6324
Weiran ZhangSchool of Basic Medical Sciences Chongqing Medical University Chongqing China.ORCID https://orcid.org/0000-0002-3276-7842
Yang JinDepartment of Biosciences University of Oslo Oslo Norway.ORCID https://orcid.org/0000-0002-7996-048X
Chaoyang SunCancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.ORCID https://orcid.org/0000-0003-2469-1638
Afshin SamaliApoptosis Research Centre, School of Biological and Chemical Sciences University of Galway Galway Ireland.ORCID https://orcid.org/0000-0002-8610-8375
Shunqing XuDepartment of Environmental Health, School of Environmental Science and Technology Hainan University Haikou China.ORCID https://orcid.org/0000-0002-7771-3821
Xia ShengInstitute of Biomedical Research, School of Life and Health Sciences Hainan University Haikou China.ORCID https://orcid.org/0000-0002-8742-7343

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impact of representative environmental chemicals on tumor immune microenvironment (TIME). Representative environmental chemicals are ubiquitously distributed across air, soil, aquatic systems, and biota. These toxicants enter the human body via multiple exposure routes, including inhalation, dietary intake, and dermal absorption, subsequently accumulating in vital organs (such as the liver, lungs, kidneys, and intestines) as well as within tumor tissues. By disrupting physiological homeostasis, they impair the functionality of critical biological systems, including the metabolic, nervous, circulatory, and immune systems. Notably, within tumor tissues, these chemicals remodel the TIME by suppressing antitumor immunity and compromising the efficacy of immunotherapy, thereby promoting tumor initiation and progression.

Identifiers

PMID42662053
PMCPMC13519100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.