ArticleFrontiers in pediatrics2026
Clinical correlation of A2063G gene mutation in mycoplasma pneumoniae pneumonia in children: a retrospective analysis.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the correlation between the A2063G point mutation in the 23S rRNA resistance gene and the clinical features of Mycoplasma pneumoniae pneumonia (MPP) in children. Methods: A retrospective analysis was conducted on 279 children diagnosed with MPP and hospitalized at Xiamen Hospital of Traditional Chinese Medicine from 2023. Based on the results of drug resistance gene sequencing, the patients were divided into a non-mutation group and a mutation group, and their clinical data were compared. Results: No significant differences were observed between the two groups regarding symptoms of productive cough and wheezing, or in laboratory indicators including white blood cell count (WBC), creatine kinase (CK), creatine kinase-MB (CK-MB), alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), and serum creatinine (Scr) ( Conclusion: The A2063G mutation may be associated with prolonged hospital stay, total fever duration, glucocorticoid use, and elevated serum CRP, D-D, and LDH levels. Furthermore, certain independent correlations are present between these clinical parameters. Early identification of this mutation during the initial stages of the disease could provide crucial guidance for adjusting clinical management strategies.
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